May 18


​Sadness & Depression


Everyone has experienced sadness and unhappiness. These may result from (1) the loss or absence of a valued person, object, or situation, or (2) troublesome thinking, behavior, and interaction patterns. Depression is a disturbance in the flow of neural information due to changes in brain chemistry. The body’s ability to feel, think, move and even digest is literally depressed! An estimated 15% to 25% of the population will experience depression at some time in their lives. Thoughts of defeat, deprivation, and self-devaluation that accompany depression suggest it is a “mental problem.” Even these may result from brain chemistry rather than life experiences.


Depressed people have low levels of norepinephrine and serotonin. These chemical messengers enable us to respond to and transmit incoming neural information. When serotonin is lacking, everything in the body slows down. Studies have shown that the brains of people who commit suicide have fewer “binding sites” that permit proper distribution of serotonin. There are several ways to disturb the delicate chemical balance needed for mood stability:

  • Heredity can affect the body’s ability to produce and use serotonin. Genes are particularly suspect when depressed people have a close relative with a mood disorder.
  • Illnesses such as anemia, cancer, chronic pain, and immune deficiencies can physically influence mood. Thyroid problems are present in 10% to 15% of depressed people.
  • Some medications for high blood pressure, heart problems, Parkinson’s disease, hormone replacement, and birth control can trigger depression.
  • Hormone levels of estrogen, progesterone, and melatonin change dramatically monthly or seasonally and may be major players in the chemistry of depression. Both serotonin and melatonin are found to be lower in some women suffering from PMS.
  • Abuse of alcohol and drugs may ultimately lead to depression even though they are initially mood enhancing. Studies show that women and children are often depressed before they begin abusing alcohol or drugs.
  • Traumatic experiences early in life may actually alter body chemistry. People who have lost a parent in childhood are twice as likely to have major depression as adults.
  • Prolonged stress can wear down the body’s reserves and lead to depression. People also acquire beliefs during trauma and high stress that influence moods. About 25% of depressed compared to 5% of nondepressed people are experiencing serious stress.

​Experiments with mice show that a combination of factors is the most likely cause of depression. Some strains of mice exposed to inescapable electric shocks develop “depressed” eating, sleeping, mating, and learning habits. They continue to deteriorate even after shocks are stopped. Other strains of mice bounce back to normal when they are no longer subject to shocks. This may suggest that even prolonged stress will not result in depression unless people are genetically predisposed.


Sadness can be caused by any change in familiar patterns of behavior that is experienced as loss: death, divorce, moving, retirement, graduation, and illness. Grief is far different from the

inability to experience pleasure that accompanies depression. It may be barely noticeable with minor disappointments or an outpouring of feelings during major loss. When sadness is mistaken for depression, feelings can be compounded and frightening. When depression is mistaken for sadness, people may not receive proper medical attention. Therefore, it is important to make the distinction:

  • Sadness is an e-motion, or energy-in-motion. Focusing on sad feelings, allowing them to build, and releasing them through crying and/or talking leads to a healing outlook. Avoiding painful feelings suppresses them and can eventually lead to depression. When properly weathered, daylight follows these “dark nights of the soul.”
  • Depression is a motionless, vacant state. Struggling to release feelings that aren’t there can be exhausting and add to the problem. An energizing distraction or medication may be needed to banish the darkness.

DIRECTIONS: Mark items that best describe your experience. Although sadness and depression can be mixed, the more pronounced condition needs to be addressed first.

Depression Indicators  inability to feel

Grief Reactions Feelings of

Pleasure, hope, love, or attachment

Sadness, missing, disappointment, or love

Emotionally “flat”

Numbness in the first few hours



Poor concentration due to difficulty pulling thoughts together, slow thinking

Poor concentration due to preoccupation


Increased desire to eat.



“I’m disgusting, worthless, inadequate.”

“I’m alone, incomplete, empty, abandoned.”

“I’ve done something wrong; I’m at fault.”

“I didn’t do enough. I should have. . . .”

“Nothing will work out.”

“I cannot trust anyone.”

“I cannot do anything. Nothing helps.”

“I have no purpose. I cannot go on.”

“Death would be a relief.”

“Death would be an escape.”



Loss of will, desire, interest

Avoidance of or desire to talk about loss

Avoidance of people, work, and activity

Focus on loss interferes with other pursuits



Disrupted sleep: too much or too little

Disrupted sleep: too much or too little

Poor appetite or overeating

Poor appetite or over eating

Weight loss or gain

Weight loss or gain

Reduced or no ability to respond sexually

Sexual responsiveness varies

Possible crying spells without knowing why

Likely bouts of sobbing over loss



Restless or slowed activity/speech

Emotional roller coaster: up and down

Reduced talking, smiling, motion, energy

Drained or exhausted


See You Mean I Don’t Have to Feel This Way by Colette Dowling (Bantam Books, 1993), p. 37,

41, 92.Depression versus Sadness Checklist

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